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AKR1C4

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GENERAL INFORMATION

Gene name

 AKR1C4

Gene description

 Aldo-keto reductase family 1, member C4

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus, cytosol & nucleoli (fibrillar center). In addition localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Cell line enriched (HDLM-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (uncertain), Nucleoli fibrillar center (uncertain), Cytosol (uncertain)

Additional location

 In addition localized to the Endoplasmic reticulum (uncertain)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA068265
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HDLM-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus, cytosol & nucleoli (fibrillar center). In addition localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Nucleus (uncertain), Nucleoli fibrillar center (uncertain), Cytosol (uncertain)

Additional location

 Endoplasmic reticulum (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA068265 A549 Nucleus Spatial
Nucleoli fibrillar center Spatial
Endoplasmic reticulum
Cytosol Spatial
HPA068265 Hep G2 Nucleus Spatial
Nucleoli fibrillar center
Endoplasmic reticulum
Cytosol Spatial
HPA068265 U-2 OS Nucleoli fibrillar center

GENE INFORMATION

Gene name

 AKR1C4 (HGNC Symbol)

Synonyms

 3-alpha-HSD, C11, CDR, CHDR, DD4, HAKRA, MGC22581

Description

 Aldo-keto reductase family 1, member C4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p15.1

Chromosome location (bp)

 5195462 - 5218949

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198610 (version 83.38)

Entrez gene

 1109

UniProt

 P17516 (UniProt - Evidence at protein level)

neXtProt

 NX_P17516

Antibodypedia

 AKR1C4 antibodies

PROTEIN BROWSER
AKR1C4-001
AKR1C4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKR1C4-001
ENSP00000369814
ENST00000380448
P17516 [Direct mapping]
Aldo-keto reductase family 1 member C4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001758 [retinal dehydrogenase activity]
GO:0004033 [aldo-keto reductase (NADP) activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006699 [bile acid biosynthetic process]
GO:0007603 [phototransduction, visible light]
GO:0008202 [steroid metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0008209 [androgen metabolic process]
GO:0009055 [electron carrier activity]
GO:0015125 [bile acid transmembrane transporter activity]
GO:0015721 [bile acid and bile salt transport]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0044281 [small molecule metabolic process]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0047023 [androsterone dehydrogenase activity]
GO:0047743 [chlordecone reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071395 [cellular response to jasmonic acid stimulus]
Show all
 323 aa
37.1 kDa 		No 0
AKR1C4-201
ENSP00000263126
ENST00000263126
P17516 [Direct mapping]
Aldo-keto reductase family 1 member C4
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001758 [retinal dehydrogenase activity]
GO:0004033 [aldo-keto reductase (NADP) activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006699 [bile acid biosynthetic process]
GO:0007603 [phototransduction, visible light]
GO:0008202 [steroid metabolic process]
GO:0008206 [bile acid metabolic process]
GO:0008209 [androgen metabolic process]
GO:0009055 [electron carrier activity]
GO:0015125 [bile acid transmembrane transporter activity]
GO:0015721 [bile acid and bile salt transport]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0044281 [small molecule metabolic process]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0047023 [androsterone dehydrogenase activity]
GO:0047743 [chlordecone reductase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071395 [cellular response to jasmonic acid stimulus]
Show all
 323 aa
37.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.