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Gene name

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Cell line

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Cancer

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MDM4
  • TISSUE

  • premium

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

MDM4

Gene description

MDM4, p53 regulator

Protein class

Cancer-related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

12
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Mainly nuclear expression in all tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

Approved based on 1 antibody.
HPA018919
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

MDM4 (HGNC Symbol)

Synonyms

HDMX, MDMX

Description

MDM4, p53 regulator (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

204516379 - 204558120

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198625 (version 83.38)

Entrez gene

4194

UniProt

O15151 (UniProt - Evidence at protein level)

neXtProt

NX_O15151

Antibodypedia

MDM4 antibodies

PROTEIN BROWSER

«
MDM4-001
MDM4-006
MDM4-007
MDM4-009
MDM4-201
MDM4-202
MDM4-203
MDM4-204
MDM4-205
MDM4-206
MDM4-207
MDM4-208
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MDM4-001
ENSP00000356150
ENST00000367182
O15151 [Direct mapping]
Protein Mdm4
A0A024R990 [Target identity:100%; Query identity:100%]
Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (Mouse), isoform CRA_a
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0002027 [regulation of heart rate]
GO:0003170 [heart valve development]
GO:0003181 [atrioventricular valve morphogenesis]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003281 [ventricular septum development]
GO:0003283 [atrial septum development]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006461 [protein complex assembly]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0019899 [enzyme binding]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0042177 [negative regulation of protein catabolic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045023 [G0 to G1 transition]
GO:0050821 [protein stabilization]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
Show all
490 aa
54.9 kDa
No 0
MDM4-006
ENSP00000356147
ENST00000367179
Q5T0Y2 [Direct mapping]
Protein Mdm4
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Show all
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
213 aa
24.2 kDa
No 0
MDM4-007
ENSP00000395254
ENST00000444261
Q5T0Y3 [Direct mapping]
Protein Mdm4
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0008270 [zinc ion binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
171 aa
19.6 kDa
No 0
MDM4-009
ENSP00000356148
ENST00000367180
Q5T0Y4 [Direct mapping]
Protein Mdm4
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
131 aa
14.6 kDa
No 0
MDM4-201
ENSP00000356151
ENST00000367183
O15151 [Direct mapping]
Protein Mdm4
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006461 [protein complex assembly]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0019899 [enzyme binding]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0042177 [negative regulation of protein catabolic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045023 [G0 to G1 transition]
GO:0050821 [protein stabilization]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
Show all
164 aa
18.2 kDa
No 0
MDM4-202
ENSP00000375811
ENST00000391947
Q68DC0 [Direct mapping]
MDM4 protein variant G; MDM4 protein variant Y; Protein Mdm4; Putative uncharacterized protein DKFZp781B1423; cDNA FLJ56709, highly similar to Mdm4 protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
140 aa
15.9 kDa
No 0
MDM4-203
ENSP00000396840
ENST00000454264
O15151 [Direct mapping]
Protein Mdm4
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006461 [protein complex assembly]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0019899 [enzyme binding]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0042177 [negative regulation of protein catabolic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0045023 [G0 to G1 transition]
GO:0050821 [protein stabilization]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
Show all
440 aa
49.5 kDa
No 0
MDM4-204
ENSP00000443816
ENST00000507825
Q68DC0 [Direct mapping]
MDM4 protein variant G; MDM4 protein variant Y; Protein Mdm4; Putative uncharacterized protein DKFZp781B1423; cDNA FLJ56709, highly similar to Mdm4 protein
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
140 aa
15.9 kDa
No 0
MDM4-205
ENSP00000478080
ENST00000612738
A0A087WTR9 [Direct mapping]
Protein Mdm4
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
267 aa
29.9 kDa
No 0
MDM4-206
ENSP00000482388
ENST00000614459
A0A087WZ58 [Direct mapping]
Protein Mdm4
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
392 aa
44 kDa
No 0
MDM4-207
ENSP00000478581
ENST00000616250
A0A087WUE3 [Direct mapping]
Protein Mdm4
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
116 aa
12.8 kDa
No 0
MDM4-208
ENSP00000482479
ENST00000621032
Q6MZR7 [Direct mapping]
Protein Mdm4; Putative uncharacterized protein DKFZp686B01123
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0071157 [negative regulation of cell cycle arrest]
Show all
153 aa
17.3 kDa
No 0

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The Human Protein Atlas project is funded
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