Expression of FAM3D in cancer - Summary - The Human Protein Atlas

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FAM3D

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM3D
Gene description	Family with sequence similarity 3, member D
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (colorectal cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (colon, rectum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA013844
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable) and breast cancer (favourable).
Head and neck cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013844

GENE INFORMATION
Gene name	FAM3D (HGNC Symbol)
Synonyms	EF7, OIT1
Description	Family with sequence similarity 3, member D (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p14.2
Chromosome location (bp)	58633946 - 58666848
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198643 (version 83.38)
Entrez gene	131177
UniProt	Q96BQ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96BQ1
Antibodypedia	FAM3D antibodies

PROTEIN BROWSER

FAM3D-001	FAM3D-002	FAM3D-003	FAM3D-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM3D-001 ENSP00000351632 ENST00000358781	Q96BQ1 [Direct mapping] Protein FAM3D A0A0A8K9B4 [Target identity:100%; Query identity:100%] Family with sequence similarity 3, member D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005125 [cytokine activity] GO:0005576 [extracellular region] GO:0046676 [negative regulation of insulin secretion] Show all	224 aa 25 kDa	No	1
FAM3D-002 ENSP00000417099 ENST00000483787	C9J5Z5 [Direct mapping] Protein FAM3D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	151 aa 16.6 kDa	No	1
FAM3D-003 ENSP00000418982 ENST00000498347	C9IZW7 [Direct mapping] Protein FAM3D Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	102 aa 11.5 kDa	No	0
FAM3D-005 ENSP00000417453 ENST00000489857	C9JB68 [Direct mapping] Protein FAM3D Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		112 aa 12 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.