Expression of LPA in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	LPA
Gene description	Lipoprotein, Lp(a)
Protein class	Candidate cardiovascular disease genes Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct positivity in plasma and cytoplasmic and membranous expression in hepatocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA060604 , CAB016072
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA060604	CAB016072

GENE INFORMATION
Gene name	LPA (HGNC Symbol)
Synonyms	LP
Description	Lipoprotein, Lp(a) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]
Chromosome	6
Cytoband
Chromosome location (bp)	160531483 - 160664259
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198670 (version 83.38)
Entrez gene	4018
UniProt	P08519 (UniProt - Evidence at protein level)
neXtProt	NX_P08519
Antibodypedia	LPA antibodies

PROTEIN BROWSER

LPA-001	LPA-201	LPA-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LPA-001 ENSP00000321334 ENST00000316300	P08519 [Direct mapping] Apolipoprotein(a) Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001968 [fibronectin binding] GO:0004252 [serine-type endopeptidase activity] GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0006898 [receptor-mediated endocytosis] GO:0008015 [blood circulation] GO:0008201 [heparin binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0034185 [apolipoprotein binding] GO:0034358 [plasma lipoprotein particle] GO:0042157 [lipoprotein metabolic process] GO:0044281 [small molecule metabolic process] Show all	2040 aa 226.5 kDa	Yes	0
LPA-201 ENSP00000395608 ENST00000447678	P08519 [Direct mapping] Apolipoprotein(a) Show all	Enzymes Peptidases Serine-type peptidases Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001968 [fibronectin binding] GO:0004252 [serine-type endopeptidase activity] GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0006898 [receptor-mediated endocytosis] GO:0008015 [blood circulation] GO:0008201 [heparin binding] GO:0010951 [negative regulation of endopeptidase activity] GO:0034185 [apolipoprotein binding] GO:0034358 [plasma lipoprotein particle] GO:0042157 [lipoprotein metabolic process] GO:0044281 [small molecule metabolic process] Show all	613 aa 68.7 kDa	No	0
LPA-202 ENSP00000480589 ENST00000614786	A0A087WWY0 [Direct mapping] Apolipoprotein(a) Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		571 aa 62.6 kDa	No	0