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Most cancer tissues showed weak to moderate cytoplasmic positivity. Nuclear staining was observed in a few cases. Several papillary adenocarcinomas of thyroid and a few colorectal cancers were strongly stained. A majority of squamous cell carcinomas, lymphomas, endometrial, renal, stomach and urothelial cancers were negative.
GENE INFORMATION
Gene name
TTC37 (HGNC Symbol)
Synonyms
KIAA0372, THES
Description
Tetratricopeptide repeat domain 37 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein with twenty tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Mutations in this gene are associated with trichohepatoenteric syndrome. [provided by RefSeq, Jul 2010]