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UNC13B

GENERAL INFORMATION

Gene name

 UNC13B

Gene description

 Unc-13 homolog B (C. elegans)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA024493 , HPA062300
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), lung cancer (favourable), head and neck cancer (favourable), pancreatic cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Lung cancer p<0.001
Head and neck cancer p<0.001
Pancreatic cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024493
HPA062300

GENE INFORMATION

Gene name

 UNC13B (HGNC Symbol)

Synonyms

 hmunc13, UNC13, Unc13h2

Description

 Unc-13 homolog B (C. elegans) (HGNC Symbol)

Entrez gene summary

 This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 35161992 - 35405338

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198722 (version 83.38)

Entrez gene

 10497

UniProt

 O14795 (UniProt - Evidence at protein level)

neXtProt

 NX_O14795

Antibodypedia

 UNC13B antibodies

PROTEIN BROWSER
UNC13B-001
UNC13B-002
UNC13B-004
UNC13B-201
UNC13B-202
UNC13B-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UNC13B-001
ENSP00000367756
ENST00000378495
O14795 [Direct mapping]
Protein unc-13 homolog B
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004871 [signal transducer activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007528 [neuromuscular junction development]
GO:0007588 [excretion]
GO:0010808 [positive regulation of synaptic vesicle priming]
GO:0014047 [glutamate secretion]
GO:0016081 [synaptic vesicle docking]
GO:0016082 [synaptic vesicle priming]
GO:0019992 [diacylglycerol binding]
GO:0030054 [cell junction]
GO:0031594 [neuromuscular junction]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0035556 [intracellular signal transduction]
GO:0043195 [terminal bouton]
GO:0046872 [metal ion binding]
GO:0048172 [regulation of short-term neuronal synaptic plasticity]
GO:0048786 [presynaptic active zone]
GO:0060384 [innervation]
GO:0097151 [positive regulation of inhibitory postsynaptic potential]
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 1591 aa
180.7 kDa 		No 0
UNC13B-002
ENSP00000380006
ENST00000396787
B1AM27 [Direct mapping]
Protein unc-13 homolog B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007268 [synaptic transmission]
GO:0019992 [diacylglycerol binding]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
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 1622 aa
184.3 kDa 		No 0
UNC13B-004
ENSP00000489441
ENST00000481299
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 190 aa
21.5 kDa 		No 0
UNC13B-201
ENSP00000367757
ENST00000378496
F8W8M9 [Direct mapping]
Protein unc-13 homolog B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007268 [synaptic transmission]
GO:0019992 [diacylglycerol binding]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
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 1197 aa
136.4 kDa 		No 0
UNC13B-202
ENSP00000484432
ENST00000617908
I6L9J0 [Direct mapping]
Protein unc-13 homolog B; UNC13B protein
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0007268 [synaptic transmission]
GO:0019992 [diacylglycerol binding]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
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 1197 aa
136.4 kDa 		No 0
UNC13B-203
ENSP00000479261
ENST00000619578
O14795 [Direct mapping]
Protein unc-13 homolog B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007588 [excretion]
GO:0010808 [positive regulation of synaptic vesicle priming]
GO:0014047 [glutamate secretion]
GO:0016082 [synaptic vesicle priming]
GO:0019992 [diacylglycerol binding]
GO:0030054 [cell junction]
GO:0035556 [intracellular signal transduction]
GO:0043195 [terminal bouton]
GO:0046872 [metal ion binding]
GO:0048786 [presynaptic active zone]
GO:0097151 [positive regulation of inhibitory postsynaptic potential]
Show all
 1610 aa
182.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.