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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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F5
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

F5

Gene description

Coagulation factor V (proaccelerin, labile factor)

Protein class

Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Group enriched (gallbladder, liver, placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression and extracellular positivity in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

Uncertain based on 1 antibody.
HPA002036
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PROGNOSTIC SUMMARY

Prognostic marker in stomach cancer (unfavourable).
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA002036

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Liver, pancreatic, urothelial, lung and colorectal cancer showed moderate to strong positivity. Remaining malignancies were weakly stained or negative.

GENE INFORMATION

Gene name

F5

Synonyms

Description

Coagulation factor V (proaccelerin, labile factor) (HGNC Symbol)

Entrez gene summary

This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]

Chromosome

1

Cytoband

q24.2

Chromosome location (bp)

169514166 - 169586588

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198734 (version 83.38)

Entrez gene

2153

UniProt

P12259 (UniProt - Evidence at protein level)

neXtProt

NX_P12259

Antibodypedia

F5 antibodies

PROTEIN BROWSER

F5-001
F5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F5-001
ENSP00000356771
ENST00000367797
P12259 [Direct mapping]
Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002576 [platelet degranulation]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007596 [blood coagulation]
GO:0008015 [blood circulation]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030134 [ER to Golgi transport vesicle]
GO:0030168 [platelet activation]
GO:0031091 [platelet alpha granule]
GO:0031093 [platelet alpha granule lumen]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
GO:1903561 [extracellular vesicle]
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2224 aa
251.7 kDa
Yes 0
F5-002
ENSP00000356770
ENST00000367796
A0A0A0MRJ7 [Direct mapping]
Coagulation factor V
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0030168 [platelet activation]
Show all
2229 aa
252.2 kDa
Yes 0

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The Human Protein Atlas project is funded
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