Expression of F5 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	F5
Gene description	Coagulation factor V (proaccelerin, labile factor)
Protein class	Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Group enriched (gallbladder, liver, placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression and extracellular positivity in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Reliability score	Uncertain based on 1 antibody. HPA002036
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (unfavourable).
Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA002036

GENE INFORMATION
Gene name	F5
Synonyms
Description	Coagulation factor V (proaccelerin, labile factor) (HGNC Symbol)
Entrez gene summary	This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]
Chromosome	1
Cytoband	q24.2
Chromosome location (bp)	169514166 - 169586588
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198734 (version 83.38)
Entrez gene	2153
UniProt	P12259 (UniProt - Evidence at protein level)
neXtProt	NX_P12259
Antibodypedia	F5 antibodies

PROTEIN BROWSER

F5-001	F5-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
F5-001 ENSP00000356771 ENST00000367797	P12259 [Direct mapping] Coagulation factor V Coagulation factor V heavy chain Coagulation factor V light chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002576 [platelet degranulation] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005788 [endoplasmic reticulum lumen] GO:0005886 [plasma membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0007596 [blood coagulation] GO:0008015 [blood circulation] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030134 [ER to Golgi transport vesicle] GO:0030168 [platelet activation] GO:0031091 [platelet alpha granule] GO:0031093 [platelet alpha granule lumen] GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:1903561 [extracellular vesicle] Show all	2224 aa 251.7 kDa	Yes	0
F5-002 ENSP00000356770 ENST00000367796	A0A0A0MRJ7 [Direct mapping] Coagulation factor V Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005507 [copper ion binding] GO:0030168 [platelet activation] Show all	2229 aa 252.2 kDa	Yes	0