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CDC42BPB

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GENERAL INFORMATION

Gene name

 CDC42BPB

Gene description

 CDC42 binding protein kinase beta (DMPK-like)

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles. In addition localized to the cytosol.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (approved)

Additional location

 In addition localized to the Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA022821
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles. In addition localized to the cytosol.

Main location

 Nuclear speckles (approved)

Additional location

 Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA022821 A-431 Nuclear speckles
Cytosol
HPA022821 U-2 OS Nuclear speckles
Cytosol
HPA022821 U-251 MG Nuclear speckles
Cytosol

GENE INFORMATION

Gene name

 CDC42BPB (HGNC Symbol)

Synonyms

 KIAA1124, MRCKB

Description

 CDC42 binding protein kinase beta (DMPK-like) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q32.32

Chromosome location (bp)

 102932379 - 103057462

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198752 (version 83.38)

Entrez gene

 9578

UniProt

 Q9Y5S2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5S2

Antibodypedia

 CDC42BPB antibodies

PROTEIN BROWSER
CDC42BPB-001
CDC42BPB-002
CDC42BPB-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC42BPB-001
ENSP00000355237
ENST00000361246
Q9Y5S2 [Direct mapping]
Serine/threonine-protein kinase MRCK beta
A0A024R6N2 [Target identity:100%; Query identity:100%]
Non-specific serine/threonine protein kinase
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007165 [signal transduction]
GO:0016477 [cell migration]
GO:0017048 [Rho GTPase binding]
GO:0030036 [actin cytoskeleton organization]
GO:0031032 [actomyosin structure organization]
GO:0031252 [cell leading edge]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0042641 [actomyosin]
GO:0070062 [extracellular exosome]
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 1711 aa
194.3 kDa 		No 0
CDC42BPB-002
ENSP00000453384
ENST00000559043
H0YLY0 [Direct mapping]
Serine/threonine-protein kinase MRCK beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
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 667 aa
74.5 kDa 		No 0
CDC42BPB-006
ENSP00000489452
ENST00000558321
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 129 aa
14.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.