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CNOT7

GENERAL INFORMATION

Gene name

 CNOT7

Gene description

 CCR4-NOT transcription complex, subunit 7

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CNOT7 (HGNC Symbol)

Synonyms

 CAF1

Description

 CCR4-NOT transcription complex, subunit 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

Chromosome

 8

Cytoband

 p22

Chromosome location (bp)

 17224964 - 17246878

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198791 (version 83.38)

Entrez gene

 29883

UniProt

 Q9UIV1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UIV1

Antibodypedia

 CNOT7 antibodies

PROTEIN BROWSER
CNOT7-001
CNOT7-002
CNOT7-007
CNOT7-008
CNOT7-011
CNOT7-012
CNOT7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNOT7-001
ENSP00000355279
ENST00000361272
Q9UIV1 [Direct mapping]
CCR4-NOT transcription complex subunit 7
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000290 [deadenylation-dependent decapping of nuclear-transcribed mRNA]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0004532 [exoribonuclease activity]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0031047 [gene silencing by RNA]
GO:0033962 [cytoplasmic mRNA processing body assembly]
GO:0035195 [gene silencing by miRNA]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening]
GO:0061014 [positive regulation of mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
Show all
 285 aa
32.7 kDa 		No 0
CNOT7-002
ENSP00000429093
ENST00000523917
Q9UIV1 [Direct mapping]
CCR4-NOT transcription complex subunit 7
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003723 [RNA binding]
GO:0004532 [exoribonuclease activity]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0031047 [gene silencing by RNA]
GO:0035195 [gene silencing by miRNA]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0046872 [metal ion binding]
GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening]
GO:0061014 [positive regulation of mRNA catabolic process]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
Show all
 244 aa
28.2 kDa 		No 0
CNOT7-007
ENSP00000430160
ENST00000524358
E5RGH2 [Direct mapping]
CCR4-NOT transcription complex subunit 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
Show all
 147 aa
17 kDa 		No 0
CNOT7-008
ENSP00000429079
ENST00000520178
E5RJE0 [Direct mapping]
CCR4-NOT transcription complex subunit 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
Show all
 41 aa
4.9 kDa 		No 0
CNOT7-011
ENSP00000428147
ENST00000519918
H0YAV9 [Direct mapping]
CCR4-NOT transcription complex subunit 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
Show all
 208 aa
24.1 kDa 		No 0
CNOT7-012
ENSP00000430263
ENST00000518541
H0YBT3 [Direct mapping]
CCR4-NOT transcription complex subunit 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
Show all
 91 aa
10.4 kDa 		No 0
CNOT7-201
ENSP00000487113
ENST00000628418
E5RHV9 [Direct mapping]
CCR4-NOT transcription complex subunit 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
Show all
 51 aa
6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.