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Most of the cancer tissues were weakly stained or negative. Moderate cytoplasmic immunoreactivity was seen in renal cancers and several cases of melanomas.
GENE INFORMATION
Gene name
LRIG2 (HGNC Symbol)
Synonyms
KIAA0806
Description
Leucine-rich repeats and immunoglobulin-like domains 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]