Expression of PNP in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PNP
Gene description	Purine nucleoside phosphorylase
Protein class	Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, highly abundant in epididymis, kidney and the gastrointestinal tract. Distinct positivity in red blood cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Supported based on 1 antibody. HPA001625
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA001625

GENE INFORMATION
Gene name	PNP (HGNC Symbol)
Synonyms	NP, PUNP
Description	Purine nucleoside phosphorylase (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	20468954 - 20477094
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198805 (version 83.38)
Entrez gene	4860
UniProt	P00491 (UniProt - Evidence at protein level)
neXtProt	NX_P00491
Antibodypedia	PNP antibodies

PROTEIN BROWSER

PNP-001	PNP-007	PNP-009	PNP-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PNP-001 ENSP00000354532 ENST00000361505	P00491 [Direct mapping] Purine nucleoside phosphorylase V9HWH6 [Target identity:100%; Query identity:100%] Purine nucleoside phosphorylase Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001882 [nucleoside binding] GO:0002060 [purine nucleobase binding] GO:0003824 [catalytic activity] GO:0004731 [purine-nucleoside phosphorylase activity] GO:0005576 [extracellular region] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006144 [purine nucleobase metabolic process] GO:0006148 [inosine catabolic process] GO:0006195 [purine nucleotide catabolic process] GO:0006738 [nicotinamide riboside catabolic process] GO:0006955 [immune response] GO:0008144 [drug binding] GO:0009116 [nucleoside metabolic process] GO:0016763 [transferase activity, transferring pentosyl groups] GO:0034356 [NAD biosynthesis via nicotinamide riboside salvage pathway] GO:0034418 [urate biosynthetic process] GO:0042102 [positive regulation of T cell proliferation] GO:0042278 [purine nucleoside metabolic process] GO:0042301 [phosphate ion binding] GO:0042493 [response to drug] GO:0043101 [purine-containing compound salvage] GO:0044281 [small molecule metabolic process] GO:0046638 [positive regulation of alpha-beta T cell differentiation] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] GO:0070970 [interleukin-2 secretion] Show all	289 aa 32.1 kDa	No	0
PNP-007 ENSP00000450663 ENST00000553418	G3V2H3 [Direct mapping] Purine nucleoside phosphorylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009116 [nucleoside metabolic process] GO:0043101 [purine-containing compound salvage] Show all	93 aa 10.5 kDa	No	0
PNP-009 ENSP00000451108 ENST00000554065	G3V393 [Direct mapping] Purine nucleoside phosphorylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009116 [nucleoside metabolic process] GO:0043101 [purine-containing compound salvage] Show all	61 aa 6.9 kDa	No	0
PNP-010 ENSP00000452421 ENST00000553591	G3V5M2 [Direct mapping] Purine nucleoside phosphorylase Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004731 [purine-nucleoside phosphorylase activity] GO:0006139 [nucleobase-containing compound metabolic process] GO:0009116 [nucleoside metabolic process] GO:0016763 [transferase activity, transferring pentosyl groups] GO:0043101 [purine-containing compound salvage] Show all	221 aa 24.5 kDa	Yes	0