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GK

GENERAL INFORMATION

Gene name

 GK

Gene description

 Glycerol kinase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (kidney, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in liver, small intestine and kidney.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 1 antibody.
HPA060687
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA060687

GENE INFORMATION

Gene name

 GK (HGNC Symbol)

Synonyms

 GK1, GKD

Description

 Glycerol kinase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Chromosome

 X

Cytoband

 p21.2

Chromosome location (bp)

 30653359 - 30731456

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198814 (version 83.38)

Entrez gene

 2710

UniProt

 P32189 (UniProt - Evidence at protein level)

neXtProt

 NX_P32189

Antibodypedia

 GK antibodies

PROTEIN BROWSER
GK-002
GK-003
GK-004
GK-005
GK-006
GK-009
GK-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GK-002
ENSP00000404682
ENST00000425166
H7C2A0 [Direct mapping]
Glycerol kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005975 [carbohydrate metabolic process]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
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 124 aa
13.1 kDa 		No 0
GK-003
ENSP00000368229
ENST00000378946
P32189 [Direct mapping]
Glycerol kinase
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Enzymes
   ENZYME proteins
   Transferases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004370 [glycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006071 [glycerol metabolic process]
GO:0006072 [glycerol-3-phosphate metabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019432 [triglyceride biosynthetic process]
GO:0019563 [glycerol catabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046167 [glycerol-3-phosphate biosynthetic process]
GO:0070062 [extracellular exosome]
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 530 aa
58.1 kDa 		No 0
GK-004
ENSP00000368226
ENST00000378943
P32189 [Direct mapping]
Glycerol kinase
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004370 [glycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006071 [glycerol metabolic process]
GO:0006072 [glycerol-3-phosphate metabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019432 [triglyceride biosynthetic process]
GO:0019563 [glycerol catabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046167 [glycerol-3-phosphate biosynthetic process]
GO:0070062 [extracellular exosome]
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 553 aa
60.6 kDa 		No 2
GK-005
ENSP00000368224
ENST00000378941
A6NP46 [Direct mapping]
Glycerol kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005975 [carbohydrate metabolic process]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
Show all
 118 aa
13.1 kDa 		No 0
GK-006
ENSP00000368221
ENST00000378938
H7BYD2 [Direct mapping]
Glycerol kinase
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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005975 [carbohydrate metabolic process]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
Show all
 94 aa
10 kDa 		No 0
GK-009
ENSP00000368228
ENST00000378945
P32189 [Direct mapping]
Glycerol kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004370 [glycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006071 [glycerol metabolic process]
GO:0006072 [glycerol-3-phosphate metabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019432 [triglyceride biosynthetic process]
GO:0019563 [glycerol catabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046167 [glycerol-3-phosphate biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 524 aa
57.5 kDa 		No 0
GK-201
ENSP00000401720
ENST00000427190
P32189 [Direct mapping]
Glycerol kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004370 [glycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006071 [glycerol metabolic process]
GO:0006072 [glycerol-3-phosphate metabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0009409 [response to cold]
GO:0010033 [response to organic substance]
GO:0016310 [phosphorylation]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0019432 [triglyceride biosynthetic process]
GO:0019563 [glycerol catabolic process]
GO:0042393 [histone binding]
GO:0042493 [response to drug]
GO:0042593 [glucose homeostasis]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0046167 [glycerol-3-phosphate biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 559 aa
61.2 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.