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CD247

GENERAL INFORMATION

Gene name

 CD247

Gene description

 CD247 molecule

Protein class

 CD markers
Disease related genes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, spleen)
GTEx:Group enriched (lung, small intestine, spleen)
FANTOM5:Tissue enhanced (appendix, lymph node, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA008750 , CAB004651
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, small intestine, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, lymph node, tonsil)

GENE INFORMATION

Gene name

 CD247 (HGNC Symbol)

Synonyms

 CD3H, CD3Q, CD3Z

Description

 CD247 molecule (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q24.2

Chromosome location (bp)

 167430640 - 167518610

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198821 (version 83.38)

Entrez gene

 919

UniProt

 P20963 (UniProt - Evidence at protein level)

neXtProt

 NX_P20963

Antibodypedia

 CD247 antibodies

PROTEIN BROWSER
CD247-001
CD247-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD247-001
ENSP00000375969
ENST00000392122
P20963 [Direct mapping]
T-cell surface glycoprotein CD3 zeta chain
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0031295 [T cell costimulation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042101 [T cell receptor complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050776 [regulation of immune response]
GO:0050852 [T cell receptor signaling pathway]
Show all
 163 aa
18.6 kDa 		Yes 1
CD247-002
ENSP00000354782
ENST00000362089
P20963 [Direct mapping]
T-cell surface glycoprotein CD3 zeta chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0031295 [T cell costimulation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042101 [T cell receptor complex]
GO:0042105 [alpha-beta T cell receptor complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050776 [regulation of immune response]
GO:0050852 [T cell receptor signaling pathway]
Show all
 164 aa
18.7 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.