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MT-ND3

GENERAL INFORMATION

Gene name

 MT-ND3

Gene description

 Mitochondrially encoded NADH dehydrogenase 3

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA063296
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA063296

GENE INFORMATION

Gene name

 MT-ND3 (HGNC Symbol)

Synonyms

 MTND3, NAD3, ND3

Description

 Mitochondrially encoded NADH dehydrogenase 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 MT

Cytoband

Chromosome location (bp)

 10059 - 10404

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198840 (version 83.38)

Entrez gene

 4537

UniProt

 P03897 (UniProt - Evidence at protein level)

neXtProt

 NX_P03897

Antibodypedia

 MT-ND3 antibodies

PROTEIN BROWSER
MT-ND3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MT-ND3-201
ENSP00000355206
ENST00000361227
P03897 [Direct mapping]
NADH-ubiquinone oxidoreductase chain 3
Q7GXZ5 [Target identity:100%; Query identity:100%]
NADH-ubiquinone oxidoreductase chain 3
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0006979 [response to oxidative stress]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0009642 [response to light intensity]
GO:0009725 [response to hormone]
GO:0016021 [integral component of membrane]
GO:0022904 [respiratory electron transport chain]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0071385 [cellular response to glucocorticoid stimulus]
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 115 aa
13.2 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.