Expression of DUSP27 in cancer - Summary - The Human Protein Atlas

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DUSP27

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DUSP27
Gene description	Dual specificity phosphatase 27 (putative)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, stomach cancer)
HPA (cell line):	Cell line enriched (RH-30)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA012608
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012608

GENE INFORMATION
Gene name	DUSP27
Synonyms
Description	Dual specificity phosphatase 27 (putative) (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q24.1
Chromosome location (bp)	167094045 - 167129165
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198842 (version 83.38)
Entrez gene	92235
UniProt	Q5VZP5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5VZP5
Antibodypedia	DUSP27 antibodies

PROTEIN BROWSER

DUSP27-001	DUSP27-201	DUSP27-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DUSP27-001 ENSP00000354483 ENST00000361200	Q5VZP5 [Direct mapping] Inactive dual specificity phosphatase 27 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	1158 aa 130.2 kDa	No	0
DUSP27-201 ENSP00000271385 ENST00000271385	Q5VZP5 [Direct mapping] Inactive dual specificity phosphatase 27 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	1158 aa 130.2 kDa	No	0
DUSP27-202 ENSP00000404874 ENST00000443333	Q5VZP5 [Direct mapping] Inactive dual specificity phosphatase 27 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	1158 aa 130.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.