Expression of R3HDM4 in cancer - Summary - The Human Protein Atlas

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R3HDM4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	R3HDM4
Gene description	R3H domain containing 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA043025 , HPA048638
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Urothelial cancer

STAINING SUMMARY

HPA043025	HPA048638

GENE INFORMATION
Gene name	R3HDM4 (HGNC Symbol)
Synonyms	C19orf22, MGC16353
Description	R3H domain containing 4 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	896503 - 913245
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198858 (version 83.38)
Entrez gene	91300
UniProt	Q96D70 (UniProt - Evidence at protein level)
neXtProt	NX_Q96D70
Antibodypedia	R3HDM4 antibodies

PROTEIN BROWSER

R3HDM4-001	R3HDM4-003	R3HDM4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
R3HDM4-001 ENSP00000355385 ENST00000361574	Q96D70 [Direct mapping] R3H domain-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] Show all	268 aa 30.3 kDa	No	0
R3HDM4-003 ENSP00000464744 ENST00000587975	K7EIG9 [Direct mapping] R3H domain-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] Show all	247 aa 28.2 kDa	No	0
R3HDM4-201 ENSP00000486092 ENST00000626716	K7ER32 [Direct mapping] R3H domain-containing protein 4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		45 aa 4.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.