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TSEN15

GENERAL INFORMATION

Gene name

 TSEN15

Gene description

 TSEN15 tRNA splicing endonuclease subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA029237
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and ovarian cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029237

GENE INFORMATION

Gene name

 TSEN15 (HGNC Symbol)

Synonyms

 C1orf19

Description

 TSEN15 tRNA splicing endonuclease subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from tRNA precursors. Alternative splicing results in multiple transcript variants. There is a pseudogene of this gene on chromosome 17. [provided by RefSeq, Jul 2014]

Chromosome

 1

Cytoband

 q25.3

Chromosome location (bp)

 184051677 - 184074212

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198860 (version 83.38)

Entrez gene

 116461

UniProt

 Q8WW01 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WW01

Antibodypedia

 TSEN15 antibodies

PROTEIN BROWSER
TSEN15-001
TSEN15-006
TSEN15-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TSEN15-001
ENSP00000355299
ENST00000361641
Q8WW01 [Direct mapping]
tRNA-splicing endonuclease subunit Sen15
B1ALV0 [Target identity:100%; Query identity:100%]
Chromosome 1 open reading frame 19, isoform CRA_c; cDNA FLJ40877 fis, clone UMVEN2000354, highly similar to tRNA-splicing endonuclease subunit Sen15
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000213 [tRNA-intron endonuclease activity]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006397 [mRNA processing]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
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 171 aa
18.6 kDa 		No 0
TSEN15-006
ENSP00000402002
ENST00000423085
Q8WW01 [Direct mapping]
tRNA-splicing endonuclease subunit Sen15
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006397 [mRNA processing]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
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 129 aa
13.9 kDa 		No 0
TSEN15-007
ENSP00000436996
ENST00000533373
E9PPN1 [Direct mapping]
tRNA-splicing endonuclease subunit Sen15
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 134 aa
14.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.