Expression of SFMBT2 in cancer - Summary - The Human Protein Atlas

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SFMBT2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SFMBT2
Gene description	Scm-like with four mbt domains 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (REH)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA035447 , HPA035448
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035447	HPA035448

GENE INFORMATION
Gene name	SFMBT2 (HGNC Symbol)
Synonyms	KIAA1617
Description	Scm-like with four mbt domains 2 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	p14
Chromosome location (bp)	7158624 - 7411486
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198879 (version 83.38)
Entrez gene	57713
UniProt	Q5VUG0 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VUG0
Antibodypedia	SFMBT2 antibodies

PROTEIN BROWSER

SFMBT2-001	SFMBT2-002	SFMBT2-003	SFMBT2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SFMBT2-001 ENSP00000355109 ENST00000361972	Q5VUG0 [Direct mapping] Scm-like with four MBT domains protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0010629 [negative regulation of gene expression] GO:0016235 [aggresome] GO:0042393 [histone binding] GO:0043231 [intracellular membrane-bounded organelle] Show all	894 aa 100.6 kDa	No	0
SFMBT2-002 ENSP00000369035 ENST00000379713	Q5T981 [Direct mapping] Scm-like with four MBT domains protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	186 aa 20.6 kDa	No	0
SFMBT2-003 ENSP00000369033 ENST00000379711	Q5T980 [Direct mapping] Scm-like with four MBT domains protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	160 aa 17.5 kDa	No	0
SFMBT2-201 ENSP00000380353 ENST00000397167	Q5VUG0 [Direct mapping] Scm-like with four MBT domains protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0010629 [negative regulation of gene expression] GO:0016235 [aggresome] GO:0042393 [histone binding] GO:0043231 [intracellular membrane-bounded organelle] Show all	894 aa 100.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.