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Cancer tissues displayed moderate to strong nuclear staining with additional cytoplasmic and membranous positivity in few tissues. Majority of the cases of malignant lymphomas, malignant carcinoid and liver cancers were weakly stained or negative.
GENE INFORMATION
Gene name
SMC5 (HGNC Symbol)
Synonyms
KIAA0594, SMC5L1
Description
Structural maintenance of chromosomes 5 (HGNC Symbol)
Q8IY18 [Direct mapping] Structural maintenance of chromosomes protein 5
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MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000722 [telomere maintenance via recombination] GO:0000724 [double-strand break repair via homologous recombination] GO:0000781 [chromosome, telomeric region] GO:0000803 [sex chromosome] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006974 [cellular response to DNA damage stimulus] GO:0007067 [mitotic nuclear division] GO:0016605 [PML body] GO:0016925 [protein sumoylation] GO:0030054 [cell junction] GO:0030915 [Smc5-Smc6 complex] GO:0034184 [positive regulation of maintenance of mitotic sister chromatid cohesion] GO:0035061 [interchromatin granule] GO:0035861 [site of double-strand break] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045842 [positive regulation of mitotic metaphase/anaphase transition] GO:0051301 [cell division] GO:0051984 [positive regulation of chromosome segregation] GO:0090398 [cellular senescence]