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MT-ND1

GENERAL INFORMATION

Gene name

 MT-ND1

Gene description

 Mitochondrially encoded NADH dehydrogenase 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granular pattern in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB033779
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and breast cancer (favourable).
Pancreatic cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB033779

GENE INFORMATION

Gene name

 MT-ND1 (HGNC Symbol)

Synonyms

 MTND1, NAD1, ND1

Description

 Mitochondrially encoded NADH dehydrogenase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 MT

Cytoband

Chromosome location (bp)

 3307 - 4262

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198888 (version 83.38)

Entrez gene

 4535

UniProt

 P03886 (UniProt - Evidence at protein level)

neXtProt

 NX_P03886

Antibodypedia

 MT-ND1 antibodies

PROTEIN BROWSER
MT-ND1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MT-ND1-201
ENSP00000354687
ENST00000361390
P03886 [Direct mapping]
NADH-ubiquinone oxidoreductase chain 1
U5Z754 [Target identity:100%; Query identity:100%]
NADH-ubiquinone oxidoreductase chain 1
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022904 [respiratory electron transport chain]
GO:0030425 [dendrite]
GO:0031966 [mitochondrial membrane]
GO:0033194 [response to hydroperoxide]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
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 318 aa
35.7 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.