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TOP1

GENERAL INFORMATION

Gene name

 TOP1

Gene description

 Topoisomerase (DNA) I

Protein class

 Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA019039 , CAB009058
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019039
CAB009058

GENE INFORMATION

Gene name

 TOP1

Synonyms

Description

 Topoisomerase (DNA) I (HGNC Symbol)

Entrez gene summary

 This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q12

Chromosome location (bp)

 41028818 - 41124487

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198900 (version 83.38)

Entrez gene

 7150

UniProt

 P11387 (UniProt - Evidence at protein level)

neXtProt

 NX_P11387

Antibodypedia

 TOP1 antibodies

PROTEIN BROWSER
TOP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TOP1-001
ENSP00000354522
ENST00000361337
P11387 [Direct mapping]
DNA topoisomerase 1
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Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000228 [nuclear chromosome]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003917 [DNA topoisomerase type I activity]
GO:0003918 [DNA topoisomerase type II (ATP-hydrolyzing) activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006265 [DNA topological change]
GO:0006338 [chromatin remodeling]
GO:0007059 [chromosome segregation]
GO:0007623 [circadian rhythm]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016310 [phosphorylation]
GO:0031298 [replication fork protection complex]
GO:0032922 [circadian regulation of gene expression]
GO:0040016 [embryonic cleavage]
GO:0042493 [response to drug]
GO:0043204 [perikaryon]
GO:0044822 [poly(A) RNA binding]
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 765 aa
90.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.