Fields »
ABOUT
HELP
BLOG
PRC1

GENERAL INFORMATION

Gene name

 PRC1

Gene description

 Protein regulator of cytokinesis 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and less frequently nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA034521
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA034521

GENE INFORMATION

Gene name

 PRC1 (HGNC Symbol)

Synonyms

 ASE1

Description

 Protein regulator of cytokinesis 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Chromosome

 15

Cytoband

 q26.1

Chromosome location (bp)

 90966038 - 90995629

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198901 (version 83.38)

Entrez gene

 9055

UniProt

 O43663 (UniProt - Evidence at protein level)

neXtProt

 NX_O43663

Antibodypedia

 PRC1 antibodies

PROTEIN BROWSER
PRC1-001
PRC1-002
PRC1-003
PRC1-012
PRC1-013
PRC1-014
PRC1-015
PRC1-019
PRC1-020

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRC1-001
ENSP00000377793
ENST00000394249
O43663 [Direct mapping]
Protein regulator of cytokinesis 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000022 [mitotic spindle elongation]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0019894 [kinesin binding]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0042802 [identical protein binding]
GO:0070938 [contractile ring]
Show all
 620 aa
71.6 kDa 		No 0
PRC1-002
ENSP00000409549
ENST00000442656
O43663 [Direct mapping]
Protein regulator of cytokinesis 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000022 [mitotic spindle elongation]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0019894 [kinesin binding]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0042802 [identical protein binding]
GO:0070938 [contractile ring]
Show all
 525 aa
61.4 kDa 		No 0
PRC1-003
ENSP00000354679
ENST00000361188
O43663 [Direct mapping]
Protein regulator of cytokinesis 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000022 [mitotic spindle elongation]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0019894 [kinesin binding]
GO:0019901 [protein kinase binding]
GO:0030496 [midbody]
GO:0042802 [identical protein binding]
GO:0070938 [contractile ring]
Show all
 606 aa
70.2 kDa 		No 0
PRC1-012
ENSP00000456737
ENST00000556972
H3BSJ8 [Direct mapping]
Protein regulator of cytokinesis 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000910 [cytokinesis]
GO:0008017 [microtubule binding]
Show all
 46 aa
4.7 kDa 		No 0
PRC1-013
ENSP00000451344
ENST00000555455
G3V3N7 [Direct mapping]
Protein regulator of cytokinesis 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000910 [cytokinesis]
GO:0008017 [microtubule binding]
Show all
 238 aa
26.4 kDa 		No 0
PRC1-014
ENSP00000453455
ENST00000557905
H0YM42 [Direct mapping]
Protein regulator of cytokinesis 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000910 [cytokinesis]
GO:0008017 [microtubule binding]
Show all
 154 aa
18.3 kDa 		No 0
PRC1-015
ENSP00000453117
ENST00000559811
H0YLA0 [Direct mapping]
Protein regulator of cytokinesis 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000910 [cytokinesis]
GO:0008017 [microtubule binding]
Show all
 110 aa
13 kDa 		No 0
PRC1-019
ENSP00000453977
ENST00000560423
H0YNE4 [Direct mapping]
Protein regulator of cytokinesis 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000910 [cytokinesis]
GO:0008017 [microtubule binding]
Show all
 64 aa
6.5 kDa 		No 0
PRC1-020
ENSP00000453063
ENST00000559828
H0YL53 [Direct mapping]
Protein regulator of cytokinesis 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000910 [cytokinesis]
GO:0008017 [microtubule binding]
Show all
 195 aa
23 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.