Expression of L1CAM in cancer - Summary - The Human Protein Atlas

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L1CAM

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	L1CAM
Gene description	L1 cell adhesion molecule
Protein class	CD markers Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (melanoma)
HPA (cell line):	Cell line enhanced (BJ hTERT+)
HPA (normal tissue):	Tissue enhanced (adrenal gland, cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in CNS, PNS and distal renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA005830 , CAB010896
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), lung cancer (unfavourable), renal cancer (unfavourable) and head and neck cancer (unfavourable).
Endometrial cancer p<0.001 Lung cancer p<0.001 Renal cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA005830	CAB010896

GENE INFORMATION
Gene name	L1CAM (HGNC Symbol)
Synonyms	CD171, HSAS, HSAS1, MASA, MIC5, S10, SPG1
Description	L1 cell adhesion molecule (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	153861514 - 153909223
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198910 (version 83.38)
Entrez gene	3897
UniProt	P32004 (UniProt - Evidence at protein level)
neXtProt	NX_P32004
Antibodypedia	L1CAM antibodies

PROTEIN BROWSER

L1CAM-001	L1CAM-002	L1CAM-003	L1CAM-006	L1CAM-007	L1CAM-008	L1CAM-010	L1CAM-011	L1CAM-017	L1CAM-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
L1CAM-001 ENSP00000359077 ENST00000370060	P32004 [Direct mapping] Neural cell adhesion molecule L1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006935 [chemotaxis] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007159 [leukocyte cell-cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022409 [positive regulation of cell-cell adhesion] GO:0031175 [neuron projection development] GO:0033631 [cell-cell adhesion mediated by integrin] GO:0033691 [sialic acid binding] GO:0034109 [homotypic cell-cell adhesion] GO:0042734 [presynaptic membrane] GO:0042802 [identical protein binding] GO:0043195 [terminal bouton] GO:0043621 [protein self-association] GO:0044295 [axonal growth cone] GO:0045773 [positive regulation of axon extension] GO:0050850 [positive regulation of calcium-mediated signaling] GO:0050900 [leukocyte migration] Show all	1257 aa 140 kDa	Yes	1
L1CAM-002 ENSP00000355380 ENST00000361699	P32004 [Direct mapping] Neural cell adhesion molecule L1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006935 [chemotaxis] GO:0007155 [cell adhesion] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0044295 [axonal growth cone] GO:0045773 [positive regulation of axon extension] GO:0050900 [leukocyte migration] Show all	1253 aa 139.5 kDa	Yes	1
L1CAM-003 ENSP00000359075 ENST00000370058	H3BLW5 [Direct mapping] Neural cell adhesion molecule L1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		153 aa 16.7 kDa	No	0
L1CAM-006 ENSP00000359072 ENST00000370055	P32004 [Direct mapping] Neural cell adhesion molecule L1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006935 [chemotaxis] GO:0007155 [cell adhesion] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0044295 [axonal growth cone] GO:0045773 [positive regulation of axon extension] GO:0050900 [leukocyte migration] Show all	1248 aa 138.9 kDa	Yes	1
L1CAM-007 ENSP00000397792 ENST00000455590	H0Y5C3 [Direct mapping] Neural cell adhesion molecule L1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	190 aa 21.5 kDa	No	0
L1CAM-008 ENSP00000392524 ENST00000420165	E7EMY4 [Direct mapping] Neural cell adhesion molecule L1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	90 aa 10.3 kDa	Yes	0
L1CAM-010 ENSP00000396079 ENST00000458029	E9PHJ4 [Direct mapping] Neural cell adhesion molecule L1 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	84 aa 9.7 kDa	Yes	0
L1CAM-011 ENSP00000402407 ENST00000439496	E7EPI4 [Direct mapping] Neural cell adhesion molecule L1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	151 aa 17.1 kDa	Yes	0
L1CAM-017 ENSP00000384902 ENST00000407935	E7EVM4 [Direct mapping] Neural cell adhesion molecule L1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	128 aa 14.5 kDa	Yes	0
L1CAM-201 ENSP00000354712 ENST00000361981	P32004 [Direct mapping] Neural cell adhesion molecule L1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006935 [chemotaxis] GO:0007155 [cell adhesion] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0044295 [axonal growth cone] GO:0045773 [positive regulation of axon extension] GO:0050900 [leukocyte migration] Show all	1248 aa 138.9 kDa	Yes	1

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