Expression of C1orf174 in cancer - Summary - The Human Protein Atlas

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C1orf174

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C1orf174
Gene description	Chromosome 1 open reading frame 174
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA008270
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and melanoma (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008270

GENE INFORMATION
Gene name	C1orf174 (HGNC Symbol)
Synonyms	RP13-531C17.2
Description	Chromosome 1 open reading frame 174 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p36.32
Chromosome location (bp)	3889125 - 3900293
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198912 (version 83.38)
Entrez gene	339448
UniProt	Q8IYL3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IYL3
Antibodypedia	C1orf174 antibodies

PROTEIN BROWSER

C1orf174-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C1orf174-001 ENSP00000355306 ENST00000361605	Q8IYL3 [Direct mapping] UPF0688 protein C1orf174 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] Show all	243 aa 26 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.