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NOS1AP

GENERAL INFORMATION

Gene name

 NOS1AP

Gene description

 Nitric oxide synthase 1 (neuronal) adaptor protein

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HEL)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in neuronal cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 3 antibodies.
HPA030066 , HPA055561 , CAB018582
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA030066
HPA055561
CAB018582

GENE INFORMATION

Gene name

 NOS1AP (HGNC Symbol)

Synonyms

 CAPON, KIAA0464

Description

 Nitric oxide synthase 1 (neuronal) adaptor protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 162069774 - 162370475

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198929 (version 83.38)

Entrez gene

 9722

UniProt

 O75052 (UniProt - Evidence at protein level)

neXtProt

 NX_O75052

Antibodypedia

 NOS1AP antibodies

PROTEIN BROWSER
NOS1AP-001
NOS1AP-002
NOS1AP-007
NOS1AP-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOS1AP-001
ENSP00000355133
ENST00000361897
O75052 [Direct mapping]
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003062 [regulation of heart rate by chemical signal]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005901 [caveola]
GO:0010628 [positive regulation of gene expression]
GO:0010750 [positive regulation of nitric oxide mediated signal transduction]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0031965 [nuclear membrane]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0042383 [sarcolemma]
GO:0042981 [regulation of apoptotic process]
GO:0045428 [regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050998 [nitric-oxide synthase binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0098901 [regulation of cardiac muscle cell action potential]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1902261 [positive regulation of delayed rectifier potassium channel activity]
GO:1902514 [regulation of generation of L-type calcium current]
GO:1902937 [inward rectifier potassium channel complex]
GO:1903762 [positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
GO:1990454 [L-type voltage-gated calcium channel complex]
GO:2000170 [positive regulation of peptidyl-cysteine S-nitrosylation]
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 506 aa
56.1 kDa 		No 0
NOS1AP-002
ENSP00000435711
ENST00000464284
E9PIP8 [Direct mapping]
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 81 aa
8.6 kDa 		No 0
NOS1AP-007
ENSP00000434988
ENST00000493151
O75052 [Direct mapping]
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003062 [regulation of heart rate by chemical signal]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005901 [caveola]
GO:0010628 [positive regulation of gene expression]
GO:0010750 [positive regulation of nitric oxide mediated signal transduction]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0031965 [nuclear membrane]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0042383 [sarcolemma]
GO:0042981 [regulation of apoptotic process]
GO:0045428 [regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050998 [nitric-oxide synthase binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0098901 [regulation of cardiac muscle cell action potential]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1902261 [positive regulation of delayed rectifier potassium channel activity]
GO:1902514 [regulation of generation of L-type calcium current]
GO:1902937 [inward rectifier potassium channel complex]
GO:1903762 [positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
GO:1990454 [L-type voltage-gated calcium channel complex]
GO:2000170 [positive regulation of peptidyl-cysteine S-nitrosylation]
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 211 aa
23 kDa 		Yes 0
NOS1AP-008
ENSP00000431586
ENST00000530878
O75052 [Direct mapping]
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003062 [regulation of heart rate by chemical signal]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005901 [caveola]
GO:0010628 [positive regulation of gene expression]
GO:0010750 [positive regulation of nitric oxide mediated signal transduction]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0031965 [nuclear membrane]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0042383 [sarcolemma]
GO:0042981 [regulation of apoptotic process]
GO:0045428 [regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050998 [nitric-oxide synthase binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0098901 [regulation of cardiac muscle cell action potential]
GO:1901381 [positive regulation of potassium ion transmembrane transport]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1902261 [positive regulation of delayed rectifier potassium channel activity]
GO:1902514 [regulation of generation of L-type calcium current]
GO:1902937 [inward rectifier potassium channel complex]
GO:1903762 [positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization]
GO:1990454 [L-type voltage-gated calcium channel complex]
GO:2000170 [positive regulation of peptidyl-cysteine S-nitrosylation]
Show all
 501 aa
55.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.