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NAGA

GENERAL INFORMATION

Gene name

 NAGA

Gene description

 N-acetylgalactosaminidase, alpha-

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA000649
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000649

GENE INFORMATION

Gene name

 NAGA (HGNC Symbol)

Synonyms

 D22S674

Description

 N-acetylgalactosaminidase, alpha- (HGNC Symbol)

Entrez gene summary

 NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q13.2

Chromosome location (bp)

 42058354 - 42070842

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198951 (version 83.38)

Entrez gene

 4668

UniProt

 P17050 (UniProt - Evidence at protein level)

neXtProt

 NX_P17050

Antibodypedia

 NAGA antibodies

PROTEIN BROWSER
NAGA-001
NAGA-002
NAGA-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NAGA-001
ENSP00000384603
ENST00000402937
P17050 [Direct mapping]
Alpha-N-acetylgalactosaminidase
A0A024R1Q5 [Target identity:100%; Query identity:100%]
N-acetylgalactosaminidase, alpha-, isoform CRA_a
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004557 [alpha-galactosidase activity]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0008456 [alpha-N-acetylgalactosaminidase activity]
GO:0009311 [oligosaccharide metabolic process]
GO:0016052 [carbohydrate catabolic process]
GO:0016139 [glycoside catabolic process]
GO:0019377 [glycolipid catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0046477 [glycosylceramide catabolic process]
GO:0070062 [extracellular exosome]
Show all
 411 aa
46.6 kDa 		Yes 0
NAGA-002
ENSP00000379680
ENST00000396398
P17050 [Direct mapping]
Alpha-N-acetylgalactosaminidase
A0A024R1Q5 [Target identity:100%; Query identity:100%]
N-acetylgalactosaminidase, alpha-, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004557 [alpha-galactosidase activity]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0008456 [alpha-N-acetylgalactosaminidase activity]
GO:0009311 [oligosaccharide metabolic process]
GO:0016052 [carbohydrate catabolic process]
GO:0016139 [glycoside catabolic process]
GO:0019377 [glycolipid catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0046477 [glycosylceramide catabolic process]
GO:0070062 [extracellular exosome]
Show all
 411 aa
46.6 kDa 		Yes 0
NAGA-003
ENSP00000385283
ENST00000403363
P17050 [Direct mapping]
Alpha-N-acetylgalactosaminidase
A0A024R1Q5 [Target identity:100%; Query identity:100%]
N-acetylgalactosaminidase, alpha-, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004557 [alpha-galactosidase activity]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0008456 [alpha-N-acetylgalactosaminidase activity]
GO:0009311 [oligosaccharide metabolic process]
GO:0016052 [carbohydrate catabolic process]
GO:0016139 [glycoside catabolic process]
GO:0019377 [glycolipid catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0046477 [glycosylceramide catabolic process]
GO:0070062 [extracellular exosome]
Show all
 411 aa
46.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.