Expression of OR10R2 in cancer - Summary - The Human Protein Atlas

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OR10R2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OR10R2
Gene description	Olfactory receptor, family 10, subfamily R, member 2
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enriched (MOLT-4)
HPA (normal tissue):	Not detected

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression

ANTIBODY IHC RELIABILITY
Data reliability description	No RNA expression data detected and pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA059775 , HPA060399
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059775	HPA060399

GENE INFORMATION
Gene name	OR10R2 (HGNC Symbol)
Synonyms	OR10R2Q
Description	Olfactory receptor, family 10, subfamily R, member 2 (HGNC Symbol)
Entrez gene summary	Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q23.1
Chromosome location (bp)	158479878 - 158480885
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000198965 (version 83.38)
Entrez gene	343406
UniProt	Q8NGX6 (UniProt - Inferred from homology)
neXtProt	NX_Q8NGX6
Antibodypedia	OR10R2 antibodies

PROTEIN BROWSER

OR10R2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OR10R2-001 ENSP00000357134 ENST00000368152	Q8NGX6 [Direct mapping] Olfactory receptor 10R2 Show all	G-protein coupled receptors Odorant/olfactory and gustatory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004984 [olfactory receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0050907 [detection of chemical stimulus involved in sensory perception] GO:0050911 [detection of chemical stimulus involved in sensory perception of smell] Show all	335 aa 37.5 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.