Cell atlas - INF2 - The Human Protein Atlas

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INF2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Nuclear bodies

Human cell
	Endoplasmic Reticulum
	Nucleoplasm

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GENERAL INFORMATION
Gene name	INF2
Gene description	Inverted formin, FH2 and WH2 domain containing
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endoplasmic reticulum. In addition localized to the nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)
Additional location	In addition localized to the Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA000724
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endoplasmic reticulum. In addition localized to the nuclear bodies.

Main location

Endoplasmic reticulum (approved)

Additional location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA000724	A-431	Endoplasmic reticulum
	HPA000724	U-2 OS	Endoplasmic reticulum
	HPA000724	U-251 MG	Nuclear bodies
	HPA000724	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	INF2 (HGNC Symbol)
Synonyms	C14orf151, C14orf173, MGC13251
Description	Inverted formin, FH2 and WH2 domain containing (HGNC Symbol)
Entrez gene summary	This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.[provided by RefSeq, Aug 2010]
Chromosome	14
Cytoband	q32.33
Chromosome location (bp)	104689606 - 104722535
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000203485 (version 83.38)
Entrez gene	64423
UniProt	Q27J81 (UniProt - Evidence at protein level)
neXtProt	NX_Q27J81
Antibodypedia	INF2 antibodies

PROTEIN BROWSER

INF2-001	INF2-003	INF2-009	INF2-010	INF2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INF2-001 ENSP00000376410 ENST00000392634	Q27J81 [Direct mapping] Inverted formin-2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] GO:0032535 [regulation of cellular component size] GO:0048471 [perinuclear region of cytoplasm] GO:0090140 [regulation of mitochondrial fission] Show all	1249 aa 135.6 kDa	No	0
INF2-003 ENSP00000376406 ENST00000330634	Q27J81 [Direct mapping] Inverted formin-2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] GO:0048471 [perinuclear region of cytoplasm] GO:0090140 [regulation of mitochondrial fission] Show all	1240 aa 134.6 kDa	No	0
INF2-009 ENSP00000381380 ENST00000398337	Q27J81 [Direct mapping] Inverted formin-2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] GO:0048471 [perinuclear region of cytoplasm] GO:0090140 [regulation of mitochondrial fission] Show all	234 aa 26 kDa	No	0
INF2-010 ENSP00000252527 ENST00000252527	A0A0A0MQU1 [Direct mapping] Inverted formin-2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0030036 [actin cytoskeleton organization] Show all	717 aa 78.8 kDa	No	0
INF2-201 ENSP00000483829 ENST00000617571	Q8WYS3 [Direct mapping] Inverted formin-2; Putative uncharacterized protein pp9484 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		142 aa 14.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.