Expression of CR1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CR1
Gene description	Complement component (3b/4b) receptor 1 (Knops blood group)
Protein class	Blood group antigen proteins CD markers Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (HL-60, HMC-1, NB-4)
HPA (normal tissue):	Tissue enhanced (appendix, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly selective expression in renal glomeruli, subsets of immune cells and follicular dendritic cells in lymphoid tissue.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 5 antibodies. HPA042455 , HPA043579 , HPA049348 , CAB002491 , CAB016271
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA042455	HPA043579	HPA049348	CAB002491	CAB016271

GENE INFORMATION
Gene name	CR1 (HGNC Symbol)
Synonyms	CD35, KN
Description	Complement component (3b/4b) receptor 1 (Knops blood group) (HGNC Symbol)
Entrez gene summary	This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q32.2
Chromosome location (bp)	207496147 - 207640647
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000203710 (version 83.38)
Entrez gene	1378
UniProt	P17927 (UniProt - Evidence at protein level)
neXtProt	NX_P17927
Antibodypedia	CR1 antibodies

PROTEIN BROWSER

CR1-001	CR1-002	CR1-003	CR1-007	CR1-011	CR1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CR1-001 ENSP00000383744 ENST00000400960	P17927 [Direct mapping] Complement receptor type 1 Show all	CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0001851 [complement component C3b binding] GO:0001855 [complement component C4b binding] GO:0001861 [complement component C4b receptor activity] GO:0002430 [complement receptor mediated signaling pathway] GO:0004877 [complement component C3b receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006958 [complement activation, classical pathway] GO:0009986 [cell surface] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0045957 [negative regulation of complement activation, alternative pathway] GO:0045959 [negative regulation of complement activation, classical pathway] GO:0046718 [viral entry into host cell] GO:0070062 [extracellular exosome] GO:1900004 [negative regulation of serine-type endopeptidase activity] GO:1900005 [positive regulation of serine-type endopeptidase activity] Show all	2039 aa 223.7 kDa	Yes	1
CR1-002 ENSP00000356018 ENST00000367051	P17927 [Direct mapping] Complement receptor type 1 Show all	CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0001851 [complement component C3b binding] GO:0001855 [complement component C4b binding] GO:0001861 [complement component C4b receptor activity] GO:0002430 [complement receptor mediated signaling pathway] GO:0004877 [complement component C3b receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006958 [complement activation, classical pathway] GO:0009986 [cell surface] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0045957 [negative regulation of complement activation, alternative pathway] GO:0045959 [negative regulation of complement activation, classical pathway] GO:0046718 [viral entry into host cell] GO:0070062 [extracellular exosome] GO:1900004 [negative regulation of serine-type endopeptidase activity] GO:1900005 [positive regulation of serine-type endopeptidase activity] Show all	2039 aa 223.6 kDa	Yes	1
CR1-003 ENSP00000356020 ENST00000367053	P17927 [Direct mapping] Complement receptor type 1 Show all	CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0001851 [complement component C3b binding] GO:0001855 [complement component C4b binding] GO:0001861 [complement component C4b receptor activity] GO:0002430 [complement receptor mediated signaling pathway] GO:0004877 [complement component C3b receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006958 [complement activation, classical pathway] GO:0009986 [cell surface] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0045957 [negative regulation of complement activation, alternative pathway] GO:0045959 [negative regulation of complement activation, classical pathway] GO:0046718 [viral entry into host cell] GO:0070062 [extracellular exosome] GO:1900004 [negative regulation of serine-type endopeptidase activity] GO:1900005 [positive regulation of serine-type endopeptidase activity] Show all	2039 aa 223.7 kDa	Yes	1
CR1-007 ENSP00000356019 ENST00000367052	Q5SR44 [Direct mapping] Complement receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	2039 aa 223.7 kDa	Yes	1
CR1-011 ENSP00000434718 ENST00000529814	H0YE06 [Direct mapping] Complement receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	661 aa 72.9 kDa	Yes	1
CR1-012 ENSP00000356016 ENST00000367049	E9PDY4 [Direct mapping] Complement receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	2489 aa 272.9 kDa	Yes	1