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LOR

GENERAL INFORMATION

Gene name

 LOR

Gene description

 Loricrin

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (melanoma)
HPA (cell line):Cell line enriched (HDLM-2)
HPA (normal tissue):Tissue enriched (skin)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 LOR

Synonyms

Description

 Loricrin (HGNC Symbol)

Entrez gene summary

 This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153259700 - 153262122

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000203782 (version 83.38)

Entrez gene

 4014

UniProt

 P23490 (UniProt - Evidence at protein level)

neXtProt

 NX_P23490

Antibodypedia

 LOR antibodies

PROTEIN BROWSER
LOR-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LOR-001
ENSP00000357731
ENST00000368742
P23490 [Direct mapping]
Loricrin
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
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GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0018149 [peptide cross-linking]
GO:0030216 [keratinocyte differentiation]
GO:0030674 [protein binding, bridging]
GO:0031424 [keratinization]
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 312 aa
25.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.