Expression of KPRP in cancer - Summary - The Human Protein Atlas

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KPRP

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KPRP
Gene description	Keratinocyte proline-rich protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (head and neck cancer, melanoma)
HPA (cell line):	Cell line enhanced (U-2197)
HPA (normal tissue):	Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in subset of cells in superficial layers of epidermis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA031988 , HPA031990
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (head and neck cancer, melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031988	HPA031990

GENE INFORMATION
Gene name	KPRP (HGNC Symbol)
Synonyms	C1orf45
Description	Keratinocyte proline-rich protein (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	152759561 - 152762052
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000203786 (version 83.38)
Entrez gene	448834
UniProt	Q5T749 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T749
Antibodypedia	KPRP antibodies

PROTEIN BROWSER

KPRP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KPRP-001 ENSP00000475216 ENST00000606109	Q5T749 [Direct mapping] Keratinocyte proline-rich protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0070062 [extracellular exosome] Show all	579 aa 64.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.