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DDO

GENERAL INFORMATION

Gene name

 DDO

Gene description

 D-aspartate oxidase

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (RPMI-8226, U-937)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA037525 , HPA037526
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
HPA037525
HPA037526

GENE INFORMATION

Gene name

 DDO

Synonyms

Description

 D-aspartate oxidase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q21

Chromosome location (bp)

 110391771 - 110415562

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000203797 (version 83.38)

Entrez gene

 8528

UniProt

 Q99489 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q99489

Antibodypedia

 DDO antibodies

PROTEIN BROWSER
DDO-001
DDO-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDO-001
ENSP00000357920
ENST00000368924
Q99489 [Direct mapping]
D-aspartate oxidase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003884 [D-amino-acid oxidase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005777 [peroxisome]
GO:0006531 [aspartate metabolic process]
GO:0006533 [aspartate catabolic process]
GO:0007320 [insemination]
GO:0007625 [grooming behavior]
GO:0008445 [D-aspartate oxidase activity]
GO:0016491 [oxidoreductase activity]
GO:0019478 [D-amino acid catabolic process]
GO:0042445 [hormone metabolic process]
GO:0046416 [D-amino acid metabolic process]
GO:0048037 [cofactor binding]
GO:0055114 [oxidation-reduction process]
GO:0071949 [FAD binding]
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 369 aa
41 kDa 		No 1
DDO-002
ENSP00000357919
ENST00000368923
Q99489 [Direct mapping]
D-aspartate oxidase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003884 [D-amino-acid oxidase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005777 [peroxisome]
GO:0006533 [aspartate catabolic process]
GO:0008445 [D-aspartate oxidase activity]
GO:0016491 [oxidoreductase activity]
GO:0019478 [D-amino acid catabolic process]
GO:0046416 [D-amino acid metabolic process]
GO:0048037 [cofactor binding]
GO:0055114 [oxidation-reduction process]
GO:0071949 [FAD binding]
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 310 aa
34 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.