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HIST2H3C

GENERAL INFORMATION

Gene name

 HIST2H3C

Gene description

 Histone cluster 2, H3c

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Correlation with RNA expression data cannot be evaluated due to technical limitations (poly-A tail missing).

Reliability score

 Supported based on 1 antibody.
HPA042570
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 HIST2H3C (HGNC Symbol)

Synonyms

 H3, H3.2, H3/m, H3F2, H3FM, MGC9629

Description

 Histone cluster 2, H3c (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015]

Chromosome

 1

Cytoband

 q21.2

Chromosome location (bp)

 149839538 - 149841193

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000203811 (version 83.38)

Entrez gene

 126961

UniProt

 Q71DI3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q71DI3

Antibodypedia

 HIST2H3C antibodies

PROTEIN BROWSER
HIST2H3C-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIST2H3C-001
ENSP00000358154
ENST00000369158
Q71DI3 [Direct mapping]
Histone H3.2
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Predicted intracellular proteins
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GO:0000183 [chromatin silencing at rDNA]
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006334 [nucleosome assembly]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0010467 [gene expression]
GO:0031047 [gene silencing by RNA]
GO:0032776 [DNA methylation on cytosine]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0044267 [cellular protein metabolic process]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
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 136 aa
15.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.