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Most cancer tissues showed moderate to strong cytoplasmic positivity. A few cases of skin, urothelial and lung cancers were weakly stained or negative.
Cancer tissues showed weak to moderate cytoplasmic immunoreactivity with additional membranous staining in several cases. Several hepatocellular carcinomas and squamous cell carcinomas were negative.
Most cancers exhibited weak to moderate cytoplasmic and/or membranous immunoreactivity. Several gliomas were strongly stained. Liver, pancreatic, gastric, renal and urothelial cancers were mainly negative.
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. [provided by RefSeq, Jul 2008]