Expression of PCMTD2 in cancer - Summary - The Human Protein Atlas

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PCMTD2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PCMTD2
Gene description	Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA057849
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable) and renal cancer (favourable).
Lung cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057849

GENE INFORMATION
Gene name	PCMTD2 (HGNC Symbol)
Synonyms	C20orf36, FLJ10883
Description	Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	64255695 - 64287821
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000203880 (version 83.38)
Entrez gene	55251
UniProt	Q9NV79 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NV79
Antibodypedia	PCMTD2 antibodies

PROTEIN BROWSER

PCMTD2-001	PCMTD2-002	PCMTD2-003	PCMTD2-005	PCMTD2-008	PCMTD2-009	PCMTD2-010	PCMTD2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCMTD2-001 ENSP00000307854 ENST00000308824	Q9NV79 [Direct mapping] Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0005737 [cytoplasm] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	361 aa 41.1 kDa	No	0
PCMTD2-002 ENSP00000358773 ENST00000369758	Q9NV79 [Direct mapping] Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0005737 [cytoplasm] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	334 aa 38.1 kDa	No	0
PCMTD2-003 ENSP00000477398 ENST00000609372	V9GZ41 [Direct mapping] Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	211 aa 24.5 kDa	No	0
PCMTD2-005 ENSP00000476726 ENST00000609818	V9GYG6 [Direct mapping] Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006479 [protein methylation] Show all	183 aa 20.8 kDa	No	0
PCMTD2-008 ENSP00000477110 ENST00000610074	V9GYZ7 [Direct mapping] Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	135 aa 15.1 kDa	No	0
PCMTD2-009 ENSP00000477252 ENST00000609764	V9GYZ7 [Direct mapping] Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	135 aa 15.1 kDa	No	0
PCMTD2-010 ENSP00000476878 ENST00000610196	V9GYL1 [Direct mapping] Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	94 aa 10.5 kDa	No	0
PCMTD2-201 ENSP00000299468 ENST00000299468	F8W9F3 [Direct mapping] Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004719 [protein-L-isoaspartate (D-aspartate) O-methyltransferase activity] GO:0006464 [cellular protein modification process] GO:0006479 [protein methylation] Show all	282 aa 31.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.