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Cytoplasmic expression in several cell types, mainly immune cells with distinct positivity in plasma.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Most malignancies were weakly stained or negative. Liver, thyroid and pancreatic cancers showed moderate cytoplasmic staining. A few cases of ovarian cancers displayed moderate to strong cytoplasmic positivity.
This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]