Expression of DPPA5 in cancer - Summary - The Human Protein Atlas

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DPPA5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DPPA5
Gene description	Developmental pluripotency associated 5
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA064505
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA064505

GENE INFORMATION
Gene name	DPPA5 (HGNC Symbol)
Synonyms	Esg1
Description	Developmental pluripotency associated 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that may function in the control of cell pluripotency and early embryogenesis. Expression of this gene is a specific marker for pluripotent stem cells. Pseudogenes of this gene are located on the short arm of chromosome 10 and the long arm of chromosomes 14 and 19. [provided by RefSeq, Dec 2010]
Chromosome	6
Cytoband	q13
Chromosome location (bp)	73353062 - 73354295
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000203909 (version 83.38)
Entrez gene	340168
UniProt	A6NC42 (UniProt - Evidence at transcript level)
neXtProt	NX_A6NC42
Antibodypedia	DPPA5 antibodies

PROTEIN BROWSER

DPPA5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPPA5-001 ENSP00000359396 ENST00000370370	A6NC42 [Direct mapping] Developmental pluripotency-associated 5 protein Show all	Predicted intracellular proteins Show all	GO:0003723 [RNA binding] GO:0005737 [cytoplasm] GO:0007275 [multicellular organismal development] Show all	116 aa 13.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.