Cell atlas - SPANXA2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SPANXA2
Gene description	SPANX family, member A2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enriched (U-2 OS)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA046423
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleoplasm (supported)

Additional location

Vesicles (approved)

1 HPA046423: A-431	2 HPA046423: A549	3 HPA046423: U-2 OS
	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
1	HPA046423	A-431	Nucleoplasm
2	HPA046423	A549	Nucleoplasm
3	HPA046423	U-2 OS	Nucleoplasm
3	HPA046423	U-2 OS	Vesicles

GENE INFORMATION
Gene name	SPANXA2 (HGNC Symbol)
Synonyms	SPANX
Description	SPANX family, member A2 (HGNC Symbol)
Entrez gene summary	Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A1 and appears to be a duplication of that locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q27.2
Chromosome location (bp)	141589435 - 141590772
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000203926 (version 83.38)
Entrez gene	728712
UniProt	Q9NS26 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NS26
Antibodypedia	SPANXA2 antibodies

PROTEIN BROWSER

SPANXA2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPANXA2-001 ENSP00000359549 ENST00000370518	Q9NS26 [Direct mapping] Sperm protein associated with the nucleus on the X chromosome A Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007283 [spermatogenesis] Show all	97 aa 11 kDa	No	0