Expression of CXorf66 in cancer - Summary - The Human Protein Atlas

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CXorf66

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CXorf66
Gene description	Chromosome X open reading frame 66
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA048517
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048517

GENE INFORMATION
Gene name	CXorf66 (HGNC Symbol)
Synonyms	RP11-35F15.2, SGPX
Description	Chromosome X open reading frame 66 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is predicted to be a type I membrane protein, however, its exact function is not known. [provided by RefSeq, Sep 2009]
Chromosome	X
Cytoband	q27.1
Chromosome location (bp)	139955725 - 139965520
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000203933 (version 83.38)
Entrez gene	347487
UniProt	Q5JRM2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5JRM2
Antibodypedia	CXorf66 antibodies

PROTEIN BROWSER

CXorf66-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CXorf66-001 ENSP00000359571 ENST00000370540	Q5JRM2 [Direct mapping] Uncharacterized protein CXorf66 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	361 aa 39.9 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.