Expression of CHIC1 in cancer - Summary - The Human Protein Atlas

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CHIC1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CHIC1
Gene description	Cysteine-rich hydrophobic domain 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with variable levels in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA026782
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026782

GENE INFORMATION
Gene name	CHIC1 (HGNC Symbol)
Synonyms	BRX
Description	Cysteine-rich hydrophobic domain 1 (HGNC Symbol)
Entrez gene summary
Chromosome	X
Cytoband	q13.2
Chromosome location (bp)	73563200 - 73687102
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204116 (version 83.38)
Entrez gene	53344
UniProt	Q5VXU3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5VXU3
Antibodypedia	CHIC1 antibodies

PROTEIN BROWSER

CHIC1-001	CHIC1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHIC1-001 ENSP00000362601 ENST00000373502	Q5VXU3 [Direct mapping] Cysteine-rich hydrophobic domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0016023 [cytoplasmic membrane-bounded vesicle] Show all	224 aa 25.6 kDa	No	1
CHIC1-004 ENSP00000362603 ENST00000373504	Q5VXU3 [Direct mapping] Cysteine-rich hydrophobic domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0016023 [cytoplasmic membrane-bounded vesicle] Show all	204 aa 23.2 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.