Expression of AGAP6 in cancer - Summary - The Human Protein Atlas

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AGAP6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AGAP6
Gene description	ArfGAP with GTPase domain, ankyrin repeat and PH domain 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA042490
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042490

GENE INFORMATION
Gene name	AGAP6 (HGNC Symbol)
Synonyms	bA324H6.1, CTGLF3
Description	ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q11.23
Chromosome location (bp)	49982190 - 50010499
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000204149 (version 83.38)
Entrez gene	414189
UniProt	Q5VW22 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5VW22
Antibodypedia	AGAP6 antibodies

PROTEIN BROWSER

AGAP6-001	AGAP6-002	AGAP6-201	AGAP6-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGAP6-001 ENSP00000400972 ENST00000412531	Q5VW22 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	686 aa 75.7 kDa	No	0
AGAP6-002 ENSP00000483426 ENST00000618025	A0A087X0I8 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	555 aa 61.3 kDa	No	0
AGAP6-201 ENSP00000363168 ENST00000374056	Q5VW22 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	663 aa 73.1 kDa	No	0
AGAP6-202 ENSP00000485012 ENST00000622418	A0A087X2I8 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6 Show all	Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0043547 [positive regulation of GTPase activity] Show all	658 aa 72.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.