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ZDHHC18

GENERAL INFORMATION

Gene name

 ZDHHC18

Gene description

 Zinc finger, DHHC-type containing 18

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA040234
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and glioma (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040234

GENE INFORMATION

Gene name

 ZDHHC18 (HGNC Symbol)

Synonyms

 DKFZp667O2416

Description

 Zinc finger, DHHC-type containing 18 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 26826710 - 26857602

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204160 (version 83.38)

Entrez gene

 84243

UniProt

 Q9NUE0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9NUE0

Antibodypedia

 ZDHHC18 antibodies

PROTEIN BROWSER
ZDHHC18-001
ZDHHC18-004
ZDHHC18-005
ZDHHC18-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZDHHC18-001
ENSP00000363257
ENST00000374142
Q9NUE0 [Direct mapping]
Palmitoyltransferase ZDHHC18
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0006612 [protein targeting to membrane]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0016409 [palmitoyltransferase activity]
GO:0018230 [peptidyl-L-cysteine S-palmitoylation]
GO:0018345 [protein palmitoylation]
GO:0019706 [protein-cysteine S-palmitoyltransferase activity]
GO:0034613 [cellular protein localization]
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 388 aa
42 kDa 		No 4
ZDHHC18-004
ENSP00000436203
ENST00000488397
H0YEN1 [Direct mapping]
Palmitoyltransferase ZDHHC18
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
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 161 aa
17.3 kDa 		No 2
ZDHHC18-005
ENSP00000363256
ENST00000374141
Q9NUE0 [Direct mapping]
Palmitoyltransferase ZDHHC18
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0006612 [protein targeting to membrane]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0016409 [palmitoyltransferase activity]
GO:0018230 [peptidyl-L-cysteine S-palmitoylation]
GO:0018345 [protein palmitoylation]
GO:0019706 [protein-cysteine S-palmitoyltransferase activity]
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 253 aa
27.9 kDa 		No 2
ZDHHC18-006
ENSP00000435510
ENST00000534643
E9PJS3 [Direct mapping]
Palmitoyltransferase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0019706 [protein-cysteine S-palmitoyltransferase activity]
Show all
 158 aa
17.9 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.