Expression of NPY4R in cancer - Summary

GENERAL INFORMATION
Gene name	NPY4R
Gene description	Neuropeptide Y receptor Y4
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (prostate cancer)
HPA (cell line):	Cell line enriched (A549)
HPA (normal tissue):	Tissue enhanced (colon, rectum)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Low cytoplasmic and membranous expression in several tissues, including gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA027863
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA027863

GENE INFORMATION
Gene name	NPY4R (HGNC Symbol)
Synonyms	PP1, PPYR1, Y4
Description	Neuropeptide Y receptor Y4 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q11.22
Chromosome location (bp)	46461099 - 46465881
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000204174 (version 83.38)
Entrez gene	5540
UniProt	P50391 (UniProt - Evidence at transcript level)
neXtProt	NX_P50391
Antibodypedia	NPY4R antibodies

PROTEIN BROWSER

NPY4R-001	NPY4R-201	NPY4R-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPY4R-001 ENSP00000379066 ENST00000395716	P50391 [Direct mapping] Neuropeptide Y receptor type 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001602 [pancreatic polypeptide receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007586 [digestion] GO:0007631 [feeding behavior] GO:0008015 [blood circulation] GO:0016021 [integral component of membrane] Show all	375 aa 42.1 kDa	No	7
NPY4R-201 ENSP00000363431 ENST00000374312	P50391 [Direct mapping] Neuropeptide Y receptor type 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001601 [peptide YY receptor activity] GO:0001602 [pancreatic polypeptide receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007586 [digestion] GO:0007631 [feeding behavior] GO:0008015 [blood circulation] GO:0016021 [integral component of membrane] GO:0042277 [peptide binding] Show all	375 aa 42.1 kDa	No	7
NPY4R-202 ENSP00000480883 ENST00000612632	P50391 [Direct mapping] Neuropeptide Y receptor type 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001602 [pancreatic polypeptide receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007586 [digestion] GO:0007631 [feeding behavior] GO:0008015 [blood circulation] GO:0016021 [integral component of membrane] Show all	375 aa 42.1 kDa	No	7