Expression of AWAT1 in cancer - Summary - The Human Protein Atlas

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AWAT1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AWAT1
Gene description	Acyl-CoA wax alcohol acyltransferase 1
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in sebaceous glands.

ANTIBODY IHC RELIABILITY
Data reliability description	No internal RNA expression data available for correlation. External characterization data supports antibody staining but no internal RNA data available for correlation. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA063412
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA063412

GENE INFORMATION
Gene name	AWAT1 (HGNC Symbol)
Synonyms	DGAT2L3
Description	Acyl-CoA wax alcohol acyltransferase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009]
Chromosome	X
Cytoband	q13.1
Chromosome location (bp)	70234655 - 70240627
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204195 (version 83.38)
Entrez gene	158833
UniProt	Q58HT5 (UniProt - Evidence at protein level)
neXtProt	NX_Q58HT5
Antibodypedia	AWAT1 antibodies

PROTEIN BROWSER

AWAT1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AWAT1-002 ENSP00000363645 ENST00000374521	Q58HT5 [Direct mapping] Acyl-CoA wax alcohol acyltransferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0016021 [integral component of membrane] GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups] GO:0019369 [arachidonic acid metabolic process] GO:0036155 [acylglycerol acyl-chain remodeling] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0047196 [long-chain-alcohol O-fatty-acyltransferase activity] Show all	328 aa 37.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.