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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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BMPR2
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

BMPR2

Gene description

Bone morphogenetic protein receptor, type II (serine/threonine kinase)

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA017385
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA017385

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tisues showed weak to moderate cytoplasmic positivity in a slightly granular pattern. Squamous cell carcinomas, urothelial cancers and lymphomas were mainly negative.

GENE INFORMATION

Gene name

BMPR2 (HGNC Symbol)

Synonyms

BMPR-II, BMPR3, BRK-3, PPH1, T-ALK

Description

Bone morphogenetic protein receptor, type II (serine/threonine kinase) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

Chromosome location (bp)

202376936 - 202567751

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204217 (version 83.38)

Entrez gene

659

UniProt

Q13873 (UniProt - Evidence at protein level)

neXtProt

NX_Q13873

Antibodypedia

BMPR2 antibodies

PROTEIN BROWSER

BMPR2-001
BMPR2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BMPR2-001
ENSP00000363708
ENST00000374580
Q13873 [Direct mapping]
Bone morphogenetic protein receptor type-2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001707 [mesoderm formation]
GO:0001893 [maternal placenta development]
GO:0001935 [endothelial cell proliferation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001946 [lymphangiogenesis]
GO:0001974 [blood vessel remodeling]
GO:0002063 [chondrocyte development]
GO:0003085 [negative regulation of systemic arterial blood pressure]
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0007420 [brain development]
GO:0009267 [cellular response to starvation]
GO:0009925 [basal plasma membrane]
GO:0009952 [anterior/posterior pattern specification]
GO:0009986 [cell surface]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0014916 [regulation of lung blood pressure]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0016362 [activin receptor activity, type II]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030308 [negative regulation of cell growth]
GO:0030425 [dendrite]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0032924 [activin receptor signaling pathway]
GO:0036122 [BMP binding]
GO:0042127 [regulation of cell proliferation]
GO:0043025 [neuronal cell body]
GO:0044214 [spanning component of plasma membrane]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045906 [negative regulation of vasoconstriction]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048286 [lung alveolus development]
GO:0048842 [positive regulation of axon extension involved in axon guidance]
GO:0060041 [retina development in camera-type eye]
GO:0060173 [limb development]
GO:0060350 [endochondral bone morphogenesis]
GO:0060836 [lymphatic endothelial cell differentiation]
GO:0060840 [artery development]
GO:0060841 [venous blood vessel development]
GO:0061036 [positive regulation of cartilage development]
GO:0061298 [retina vasculature development in camera-type eye]
GO:0071773 [cellular response to BMP stimulus]
GO:0072577 [endothelial cell apoptotic process]
GO:0097481 [neuronal postsynaptic density]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:2000279 [negative regulation of DNA biosynthetic process]
Show all
1038 aa
115.2 kDa
Yes 2
BMPR2-002
ENSP00000363702
ENST00000374574
Q13873 [Direct mapping]
Bone morphogenetic protein receptor type-2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001707 [mesoderm formation]
GO:0001935 [endothelial cell proliferation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001946 [lymphangiogenesis]
GO:0001974 [blood vessel remodeling]
GO:0002063 [chondrocyte development]
GO:0003085 [negative regulation of systemic arterial blood pressure]
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009267 [cellular response to starvation]
GO:0009952 [anterior/posterior pattern specification]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0014916 [regulation of lung blood pressure]
GO:0016020 [membrane]
GO:0016362 [activin receptor activity, type II]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030166 [proteoglycan biosynthetic process]
GO:0030308 [negative regulation of cell growth]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0032924 [activin receptor signaling pathway]
GO:0036122 [BMP binding]
GO:0042127 [regulation of cell proliferation]
GO:0044214 [spanning component of plasma membrane]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045906 [negative regulation of vasoconstriction]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048286 [lung alveolus development]
GO:0060350 [endochondral bone morphogenesis]
GO:0060836 [lymphatic endothelial cell differentiation]
GO:0060840 [artery development]
GO:0060841 [venous blood vessel development]
GO:0061036 [positive regulation of cartilage development]
GO:0061298 [retina vasculature development in camera-type eye]
GO:0071773 [cellular response to BMP stimulus]
GO:0072577 [endothelial cell apoptotic process]
GO:1902731 [negative regulation of chondrocyte proliferation]
GO:2000279 [negative regulation of DNA biosynthetic process]
Show all
530 aa
60 kDa
Yes 2

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