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Most cancer tissues showed weak to moderate cytoplasmic positivity. Few cases of ovarian cancer, squamous cell carcinomas and a few urothelial cancers showed strong immunoreactivity. Several renal cell carcinomas were negative.
Most cancer tissues showed weak to moderate cytoplasmic positivity. Several gliomas, lymphomas and liver cancers were negative.
GENE INFORMATION
Gene name
PFDN6 (HGNC Symbol)
Synonyms
H2-KE2, HKE2, KE-2, PFD6
Description
Prefoldin subunit 6 (HGNC Symbol)
Entrez gene summary
PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]