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HSD17B8

GENERAL INFORMATION

Gene name

 HSD17B8

Gene description

 Hydroxysteroid (17-beta) dehydrogenase 8

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (RPMI-8226, U-266/70)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA042132
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042132

GENE INFORMATION

Gene name

 HSD17B8 (HGNC Symbol)

Synonyms

 D6S2245E, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1

Description

 Hydroxysteroid (17-beta) dehydrogenase 8 (HGNC Symbol)

Entrez gene summary

 In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.32

Chromosome location (bp)

 33204642 - 33206831

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204228 (version 83.38)

Entrez gene

 7923

UniProt

 Q92506 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92506

Antibodypedia

 HSD17B8 antibodies

PROTEIN BROWSER
HSD17B8-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSD17B8-001
ENSP00000363794
ENST00000374662
Q92506 [Direct mapping]
Estradiol 17-beta-dehydrogenase 8
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity]
GO:0004303 [estradiol 17-beta-dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005740 [mitochondrial envelope]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0006633 [fatty acid biosynthetic process]
GO:0006703 [estrogen biosynthetic process]
GO:0008152 [metabolic process]
GO:0008209 [androgen metabolic process]
GO:0008210 [estrogen metabolic process]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0047035 [testosterone dehydrogenase (NAD+) activity]
GO:0055114 [oxidation-reduction process]
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 261 aa
27 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.