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Major histocompatibility complex, class II, DO alpha (HGNC Symbol)
Entrez gene summary
HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]
P06340 [Direct mapping] HLA class II histocompatibility antigen, DO alpha chain X5CF87 [Target identity:100%; Query identity:100%] MHC class II antigen
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002587 [negative regulation of antigen processing and presentation of peptide antigen via MHC class II] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0023026 [MHC class II protein complex binding] GO:0032395 [MHC class II receptor activity] GO:0042613 [MHC class II protein complex] GO:0045580 [regulation of T cell differentiation]
