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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AGER

Gene description

Advanced glycosylation end product-specific receptor

Protein class

Cancer-related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

11
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HEK93, U-266/70)
HPA (normal tissue):Tissue enriched (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in pneumocytes and endothelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Approved based on 1 antibody.
CAB011682
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB011682

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells displayed weak to moderate cytoplasmic immunoreactivity.

GENE INFORMATION

Gene name

AGER (HGNC Symbol)

Synonyms

RAGE

Description

Advanced glycosylation end product-specific receptor (HGNC Symbol)

Entrez gene summary

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]

Chromosome

6

Cytoband

p21.32

Chromosome location (bp)

32180968 - 32184324

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204305 (version 83.38)

Entrez gene

177

UniProt

Q15109 (UniProt - Evidence at protein level)

neXtProt

NX_Q15109

Antibodypedia

AGER antibodies

PROTEIN BROWSER

«
AGER-001
AGER-002
AGER-004
AGER-007
AGER-008
AGER-201
AGER-202
AGER-203
AGER-204
AGER-205
AGER-206
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AGER-001
ENSP00000364217
ENST00000375076
Q15109 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009611 [response to wounding]
GO:0031175 [neuron projection development]
GO:0042802 [identical protein binding]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
404 aa
42.8 kDa
Yes 1
AGER-002
ENSP00000364195
ENST00000375055
Q15109 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009611 [response to wounding]
GO:0031175 [neuron projection development]
GO:0042802 [identical protein binding]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
347 aa
37 kDa
Yes 0
AGER-004
ENSP00000364208
ENST00000375067
Q15109 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009611 [response to wounding]
GO:0031175 [neuron projection development]
GO:0042802 [identical protein binding]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
342 aa
36.2 kDa
Yes 0
AGER-007
ENSP00000364196
ENST00000375056
Q5SSZ2 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
233 aa
25.2 kDa
Yes 0
AGER-008
ENSP00000398466
ENST00000450110
Q5SSZ3 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
234 aa
25.2 kDa
Yes 0
AGER-201
ENSP00000364206
ENST00000375065
C0IP14 [Direct mapping]
Advanced glycosylation end product-specific receptor; Advanced glycosylation end product-specific receptor variant CC
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
133 aa
13.8 kDa
No 1
AGER-202
ENSP00000364210
ENST00000375069
Q15109 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007162 [negative regulation of cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007259 [JAK-STAT cascade]
GO:0007420 [brain development]
GO:0008201 [heparin binding]
GO:0009100 [glycoprotein metabolic process]
GO:0009611 [response to wounding]
GO:0009750 [response to fructose]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010508 [positive regulation of autophagy]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010763 [positive regulation of fibroblast migration]
GO:0014002 [astrocyte development]
GO:0014823 [response to activity]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0031175 [neuron projection development]
GO:0032966 [negative regulation of collagen biosynthetic process]
GO:0033189 [response to vitamin A]
GO:0033595 [response to genistein]
GO:0033689 [negative regulation of osteoblast proliferation]
GO:0035690 [cellular response to drug]
GO:0042802 [identical protein binding]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050729 [positive regulation of inflammatory response]
GO:0050785 [advanced glycation end-product receptor activity]
GO:0050930 [induction of positive chemotaxis]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051101 [regulation of DNA binding]
GO:0051595 [response to methylglyoxal]
GO:0055074 [calcium ion homeostasis]
GO:0055093 [response to hyperoxia]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0060290 [transdifferentiation]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070379 [high mobility group box 1 binding]
GO:0071333 [cellular response to glucose stimulus]
GO:0071398 [cellular response to fatty acid]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0072657 [protein localization to membrane]
GO:0072714 [response to selenite ion]
GO:1901018 [positive regulation of potassium ion transmembrane transporter activity]
GO:1901216 [positive regulation of neuron death]
GO:1904597 [negative regulation of connective tissue replacement involved in inflammatory response wound healing]
GO:1904599 [advanced glycation end-product binding]
GO:1904604 [negative regulation of advanced glycation end-product receptor activity]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2000676 [positive regulation of type B pancreatic cell apoptotic process]
Show all
420 aa
44.8 kDa
Yes 1
AGER-203
ENSP00000364211
ENST00000375070
A8MS87 [Direct mapping]
Advanced glycosylation end product-specific receptor; Advanced glycosylation end product-specific receptor variant BB
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
294 aa
31.3 kDa
No 1
AGER-204
ENSP00000387887
ENST00000438221
Q15109 [Direct mapping]
Advanced glycosylation end product-specific receptor
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009611 [response to wounding]
GO:0031175 [neuron projection development]
GO:0042802 [identical protein binding]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
363 aa
39 kDa
Yes 0
AGER-205
ENSP00000445389
ENST00000538695
B5A982 [Direct mapping]
Advanced glycosylation end product-specific receptor; Advanced glycosylation end products transcript variant; Soluble RAGE variant 5
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
128 aa
14 kDa
Yes 0
AGER-206
ENSP00000484081
ENST00000620802
Q3L1R2 [Direct mapping]
Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end-products deletion exon3-10 variant
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
153 aa
16.3 kDa
Yes 1

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