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Colorectal cancer along with several cases of breast, cervical, pancreatic and gastric cancers showed moderate cytoplasmic immunoreactivity. Remaining cancer cells were in general weakly stained or negative.
GENE INFORMATION
Gene name
RNF5 (HGNC Symbol)
Synonyms
G16, NG2, RING5, RMA1
Description
Ring finger protein 5, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]